Unlock personalized cancer care. Book a Test Now

This is to bring to your notice that SOT Therapy from RGCC is not available in Singapore

Clavic-Q-RE

A groundbreaking cancer immunotherapy treatment that harnesses the innate power of a patient's own immune system to fight cancer

In the evolving landscape of cancer care, immunotherapy is changing cancer treatment forever. We’re proud to offer Clavic-Q-RE, a groundbreaking cancer immunotherapy treatment that harnesses the innate power of a patient’s own immune system to fight cancer. This autologous approach to personalized cancer care represents the next generation of precision medicine, offering hope to patients seeking alternatives beyond traditional chemotherapy and radiation.

This therapy available to various countries (excluding Singapore).

What is Clavic-Q-RE?

Clavic-Q-RE stands as a pioneering immunotherapy treatment for cancer that is a minimally manipulated cellular therapy also known as Autologous Adoptive Cellular Therapy. This innovative therapy is a significant advancement in personalized cancer care, offering patients a targeted approach that works with their body’s natural defense mechanisms.

Autologous Adoptive Cellular Therapy
Clavic-Q-RE is classified as a non-modified, autologous use only, adoptive cellular therapy, meaning it uses the patient's own immune cells to create a personalized immunotherapy treatment. This approach removes the burden of immune rejection while maximizing therapeutic effectiveness. The therapy is created exclusively from the patient’s blood, ensuring complete biological compatibility and personalized targeting of the patient’s specific cancer.

The autologous nature of this treatment means that every dose is unique, created from one’s own immune cells and tailored to target the patient’s specific cancer antigens. This personalization is what sets new cancer treatment immunotherapy approaches like Clavic-Q-RE apart from traditional one-size-fits-all treatments.

Immune Cells
Clavic-Q-RE contains a comprehensive arsenal of both innate and adaptive immune cells, creating a multi-faceted approach to cancer treatment. The therapy includes:

Innate immune cells: Monocytes that turn into macrophages and Natural Killer (NK) cells that provide immediate, broad-spectrum cancer-fighting capability
Adaptive immune cells: Activated dendritic cells, cytotoxic T lymphocytes (CTLs), and antibody-producing plasma cells that provide targeted, long-lasting immunity

This combination ensures both immediate and sustained immune response against cancer cells, making it one of the most comprehensive cancer immunotherapy treatments available today.

How Does Clavic-Q-RE Work?

The mechanism of action behind Clavic-Q-RE demonstrates why immunotherapy in cancer treatment has become such a promising field. The therapy works through multiple complementary pathways to identify, target, and eliminate cancer cells throughout the body.

Macrophages serve as the body’s primary cleanup crew, using their phagocytic capabilities to engulf and digest cancer cells and cellular debris. These versatile immune cells can recognize and eliminate cancer cells in an MHC-independent manner, meaning they don’t need specific antigen presentation to identify threats.

Natural Killer (NK) cells function as the immune system’s rapid response team, capable of immediately recognizing and destroying cancer cells without prior sensitization. They work by detecting abnormal protein expressions on cancer cell surfaces and releasing cytotoxic granules that induce cancer cell death.

The adaptive immune response is orchestrated through dendritic cells. In Clavic-Q-RE, the dendritic cells are already activated in vivo against tumor peptides that are recognized by MHC-II or MHC-I and expressed in the patient’s sample, creating a personalized vaccine effect.

These activated dendritic cells then educate cytotoxic T lymphocytes (CTLs) to recognize and target your specific cancer cells. Once activated, these CTLs circulate throughout the body with the ability to identify and eliminate cancer cells that express the targeted antigens, providing long-lasting, memory-based immunity.

Plasma cells in the therapy have been activated in vivo against specific tumor antigens expressed in the patient’s sample. These antibodies act as molecular “tags,” marking cancer cells for destruction by other immune components. This tagging system helps coordinate the immune response and ensures that cancer cells cannot hide from immune surveillance, making it an important tool for immunotherapy in cancer treatment.

Innate Immune Cell + Adaptive Immune Cell Infusions

Clavic-Q-RE is administered as three carefully timed doses, each containing both innate and adaptive immune cells. This staged approach allows for:

  • Immediate response: Innate immune cells provide rapid cancer-fighting activity from the first dose
  • Building immunity: Adaptive immune cells develop and strengthen cancer-specific responses over time
  • Sustained protection: The combination creates both immediate and long-term anti-cancer immunity

The therapy timeline spans four weeks, with doses administered every two weeks, allowing the immune system to build upon each treatment while maintaining therapeutic momentum.

What kind of cancers can be treated with Clavic-Q-RE?

Clavic-Q-RE demonstrates effectiveness against a broad spectrum of malignancies, including:

Solid tumors: Including but not limited to breast, lung, prostate, colorectal, pancreatic, kidney, and liver cancers
Hematologic cancers: Such as leukemias, lymphomas, and multiple myeloma

The therapy's versatility stems from its ability to target patient-specific cancer antigens, making it adaptable to many different cancer types. The personalized nature of the treatment means it can be tailored to target the unique molecular signature of each patient's cancer.

What kind of cancers will not respond to Clavic-Q-RE?

Currently, Central Nervous System (CNS) cancers are not candidates for Clavic-Q-RE therapy due to the blood-brain barrier. This physiological barrier prevents the therapeutic immune cells from effectively reaching brain tumors, limiting the therapy's effectiveness in treating primary brain cancers and brain metastases.

Personalize your cancer journey

Reserve your 15-minute free one on one discussion

Why Choose Clavic-Q-RE?

Personalized Approach: Every dose is created specifically from your immune cells and targeted to your cancer antigens, ensuring maximum compatibility and effectiveness.

Comprehensive Immune Response: Unlike single-target therapies, Clavic-Q-RE activates multiple immune pathways, creating a robust, multi-faceted attack against cancer cells.

Excellent Safety Profile: As an autologous therapy, the risk of severe adverse reactions is minimized while therapeutic benefits are maximized.

Proven Science: Backed by peer-reviewed research and developed by RGCC's team of internationally recognized scientists and researchers.

Why choose Oncotrail?

Oncotrail has undergone rigorous evaluation to ensure high sensitivity and specificity, making it an invaluable tool for diagnostic purposes.

Through high-precision techniques, the test is used to monitor the effectiveness of a particular cancer treatment. This would objectively provide information on how well the treatment is going.

The non-invasive tracking of the cancer status would notify a treating physician whether to adjust current management or stay the course. This would be important to know in almost real-time rather than to find out much later that a treatment doesn't apply to a particular person.

Talk to our RGCC experts

WhatsApp me for the details of Clavic-Q-RE





    Frequently asked questions

    Clavic-Q-RE is appropriate for patients who meet specific staging criteria:

    • Minimum staging: Patients must be staged at grade 2B or higher
    • Treatment-resistant cases: Ideal for patients when conventional treatments have been exhausted
    • Stable disease: The cancer must be stable, not rapidly progressing
    • Other treatments: Patients cannot be receiving concurrent chemotherapy or radiation therapy

    This therapy often serves as an excellent option for patients seeking alternatives after conventional treatments have reached their limits, provided their overall health status supports immune-based therapy.

    Beat your burdens effectively with Clavic-Q-RE in each step